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P-alpha Synuclein (Y125) Rabbit mAb [QTRJ]Cat NO.: A39275

Western blot(SDS PAGE) analysis of extracts from 0.Using P-alpha Synuclein (Y125) Rabbit mAb [QTRJ]at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :Alpha synuclein; alphaSYN; NACP; PARK1; PARK4; Parkinson disease familial 1; SNCA; SYN; Synuclein alpha 140;

UniProtID :P37840

MASS(da) :14,460

MW(kDa) :18kDa

Form :Liquid

Purification :Affinity-chromatography

Host :Rabbit

Isotype : IgG

sensitivity :Endogenous

Reactivity :Human

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with A synthesized peptide derived from human Phospho-alpha Synuclein (Y125)

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

Function : Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:28288128, PubMed:30404828, PubMed:20798282, PubMed:26442590). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590)..

Tissue specificity :Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain..

Subcellular locationi :Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted. Cell projection, axon.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.