BNP Rabbit mAb [08MU]Cat NO.: A80692

Protein names ：NPPB,ANFB_HUMAN,Natriuretic peptides B [Cleaved into: NT-proBNP ),proBNP,Brain natriuretic peptide 32 ) ,BNP,BNP,BNP,BNP,BNP ),BNP,BNP,Brain natriuretic peptide 29 ),BNP,BNP,BNP,BNP,BNP,BNP,BNP]

UniProtID ：P16860

MASS(da) ：14,726

MW(kDa) ：30 kda

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫荧光(ICC/IF)1:100,
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide of Human BNP.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Human plasma tissue lyaste

Function ： [Brain natriuretic peptide 32]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:9458824, PubMed:1672777, PubMed:1914098, PubMed:17372040). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:9458824, PubMed:1672777, PubMed:17372040, PubMed:21098034, PubMed:17349887, PubMed:25339504). Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:9458824, PubMed:1914098). Binds the clearance receptor NPR3 (PubMed:16870210).., [NT-proBNP]: May affect cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32 (PubMed:17372040).., [BNP(3-32)]: May have a role in cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP (PubMed:17372040)..

Tissue specificity ：[Brain natriuretic peptide 32]: Detected in the cardiac atria (at protein level) (PubMed:2138890, PubMed:2136732). Detected in the kidney distal tubular cells (at protein level) (PubMed:9794555)..

Subcellular locationi ：[NT-proBNP]: Secreted.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.