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TAOK1 Rabbit mAb [2K95]Cat NO.: A49903

Western blot(SDS-PAGE) analysis of extracts from Jurkat cells lysate.using TAOK1 Rabbit mAb [2K95] at dilution of 1:1000 incubated at 4℃ over night.

  • SizePriceIn stock
  • 50ul1060.00库存充足
  • 100ul2088.00库存充足
  • 200ul3098.00库存充足
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Product information

Protein names :TAOK1,KIAA1361,MAP3K16,MARKK,TAOK1_HUMAN,Serine/threonine-protein kinase TAO1

UniProtID :Q7L7X3

MASS(da) :116,070

MW(kDa) :116KDa

Form :Rabbit IgG

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity : Human,Mouse,Rat

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide of Human TAOK1.

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected : Jurkat cells lysate

Function : Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade..

Tissue specificity :Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle..

Subcellular locationi :Cytoplasm.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.